Sinner has won 21 of his 24 titles on hard courts and looked on top form as he raced to victory against Zverev in one hour and 23 minutes.
The 24-year-old is aiming to become just the third man - after Roger Federer and Novak Djokovic - to capture all six ATP Masters 1,000 hard-court titles.
"It was a great performance - very solid from the back of the court. I tried to go for shots and that felt like one of the keys," Sinner said.
"He has a huge serve so I tried to mix it up. From my side I was very precise and it was a solid performance.
"I thought the match would be more physical but when both serve well it's difficult to get into a rhythm with short points."
Sinner has endured a frustrating start to 2026, failing to reach a final prior to this event, but was inspired as he attempts to land what by his standards is perhaps an overdue title.
It was in the first set where the mental damage was done as the Italian, who has now won seven of his 11 meetings with Zverev, dropped just four points on serve and broke twice.
Zverev struggled to find rhythm on serve in the opening set and Sinner made him pay - winning six of the eight second-serve return points.
The German, 28, stood firm to save three break points in the opening service game of the second set, but he was ultimately broken to trail 4-3 with the remainder of the match staying on serve.